Domperidone is a commonly used to promote gastric motility drugs and antiemetics, we are more familiar with it a name called butorpholine, and its other alias is also piperazine, imipramycin, chlorpheniramine, Bromide, dipropylene ketone, dipropyl ketone, etc., the appearance of white to yellowish powder, bitter, almost insoluble in water, slightly soluble in ethanol, soluble in lactic acid, soluble in Citric acid. This product is a strong peripheral dopamine receptor antagonist, domperidone can block the synaptic front and rear DA1, DA2 receptor, antagonize dopamine on the intestinal myenteric plexus synaptic cholinergic neurons induced by the inhibition Stomach contraction. Can promote the upper gastrointestinal motility and tension returned to normal, promote gastric emptying, increase the antrum and duodenal movement, coordination of pyloric contraction, but also can enhance the esophageal peristalsis and esophageal sphincter tension. Because of its poor penetration of the blood-cerebrospinal fluid barrier, there is almost no antagonistic effect on the dopamine receptor in the brain, thus eliminating the side effects of mental and central nervous system. Rapid absorption after oral administration, 15 ~ 30min peak plasma concentration. In addition to the central nervous system, in other parts of the body are widely distributed. Because of the "first effect" of liver metabolism and intestinal metabolism, oral bioavailability is low. The product of the half-life of 7h, about 30% after oral administration by the urine, 4 days about 60% excreted by the feces.

Indications