Details
Indomethacin
1-p-chlorobenzoyl-5-methoxy-2-methylindole acetic acid; indomethacin; indomethacin; indomethacin; indomethacin; (4-chlorobenzoyl) -5-methoxy-2-methyl-1H-indole-3-acetic acid
English name: Indometacin
English name: AURORA KA-6542; INDOCIN; INDOMETACIN; INDOMETACINE; INDOMETHACIN; INDOMETHACINE; LABOTEST-BB LT00244830; 1- (P-CHLOROBENZYL) -5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
CAS Number: 53-86-1
Molecular formula: C19H16ClNO4
Molecular weight: 357.79
EINECS number: 200-186-5
Indomethacin, also known as indomethacin, is a strong role in non-corticosteroid anti-inflammatory antipyretic and analgesic drugs, by inhibiting the inhibition of cyclooxygenase prostaglandin (PG) synthesis, to prevent the formation of inflammatory nerve pain nerve impulses , Inhibition of inflammatory response, including inhibition of leukocyte chemotaxis and lysosomal enzyme release, resulting in antipyretic, analgesic and anti-inflammatory effect. Indomethacin anti-inflammatory, antipyretic effect is very strong, its anti-inflammatory effect than Baotai Song 84 times stronger than hydrocortisone is also strong, and glucocorticoids, aspirin, Paul Taisong joint use, can reduce their Dosage, toxicity and side effects to improve efficacy; followed by antipyretic effect, 10 times for aminopyrine; analgesic effect is weak, only significant analgesic effect on inflammatory pain, but the effect of inflammatory pain better than Paul Taisong, analgin and salicylic acid. Clinical mainly used for salicylic acid drugs are not easy to tolerate, or the effect is not obvious acute and chronic rheumatoid or rheumatoid arthritis, ankylosing spondylitis, bursitis, tenosynovitis, joint capsule, osteoarthritis, Acute gout and cancer pain. In recent years, researchers have tried to use indomethacin for biliary colic, dysmenorrhea, migraine, glomerulonephritis, polyuria, salmonella gastroenteritis, orthostatic hypotension, Bartlett syndrome, etc. Efficacy. Can also be used to treat ophthalmic pigmented inflammation, keratitis, scleritis, glaucoma and cancer caused by fever or other difficult to control the fever. Dermatology for lupus erythematosus, Behcet's syndrome, scleroderma, nodular erythema, herpes zoster, psoriasis and so on. Topical treatment of eczema, allergic dermatitis, light sensory dermatitis, local pain.
Use of the goods anti-inflammatory, antipyretic effect is obvious, mainly for salicylic acid drugs are not easy to tolerate or no significant effect of rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and so on.
Production methods: p-amino anisole by diazotization, reduction, acidification, hydrolysis, cyclization, get indomethacin.
Nature: white or slightly yellow crystalline powder, soluble in bing ketone, slightly soluble in ethanol, chloroform, B mi, almost insoluble in water. Tasteless, almost odorless
Melting point 158-162 ° C
Content: 98.5% ~ 100.5%
Standard: Enterprise Standard / CP / BP
Head: 80% over 80 mesh
KG Pharmaceutical grade powder white 25KG / cardboard drum
China (Mainland)