Jinan Jiage biological technology co., LTD(expird)
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CAS NO.483-63-6
Enterprise Standard(1-10)GramEnterprise Standard(11-100)Gram
High quality pharma grade 99% Pharmaceutical Crotamiton for antipruritic
|
Product Name |
Crotamiton |
| Synonyms |
Crotalgin;Crotamitex;Crotamitone;Eurasil; |
| CAS |
483-63-6 |
| MF |
C13H17NO |
| MW |
203.28 |
| EINECS |
207-596-3 |
| Purity |
99% |
| Appearance |
Colorless or light yellow liquid |
| Certification |
HSE, ISO 9001, USP, BP
|
| Grade |
Pharma grade |
| Usage |
Used for a variety of allergic skin diseases and cosmetic additives |
| Storage |
Store in cool and dry area and keep away from direct sunlight |
| Packing |
Discreet packing ways as your requirement, 100% go through |
Description:
Crotamiton is a drug that is used both as a scabicidal (for treatingscabies) and as a general antipruritic
(anti-itching drug). It is a prescription lotion based medicine that is applied to the whole body to get rid of the scabies parasite that burrows under the skin and causesitching. For treating scabies, crotamiton should be applied to the whole body rather than a localized area. It is applied 2 to 3 times, with a 24 hour delay in between applications, and the patient is asked to take ashower no sooner than after 48hours. For children under 3 years it is applied once daily. Crotamiton can also be used to treat itching stemming from other causes, e.g. insect bites, in which case it is applied to the itching areas only, and repeated if necessary after 4 to 8 hours. Use near the eyes, or breaks in the skin, should be avoided.
Application:
Fifty hospitalized infants and small children in the age-group of 3 months to 2 years admitted with scabies were treated with 5 applications of either 10% crotamiton cream or lotion on consecutive days. In this trial, the second to be performed exclusively in infants and young children, an improvement in itching was observed in all patients within 3 days of starting the treatment and the examination on Day 7 showed absence of skin lesions in all patients. Crotamiton cream as well as lotion rendered a 100% cure rate. All patients, including those having secondary pyoderma and/or eczematization tolerated the treatment with crotamiton cream and lotion well and no adverse reactions, either due to the topical application or to the transcutaneous systemic absorption of crotamiton, were reported.
Post-treatment laboratory investigations did not reveal any unwanted effect due to transcutaneous systemic absorption of crotamiton on the blood, kidneys or liver. Crotamiton is the only scabicide available today which displays not only antiprurtic but also marked antibacterial properties. It is especially indicated in the treatment of scabies in children as they are very prone to secondary bacterial infection following scratching. In view of its good efficacy and excellent tolerability the 5-application treatment schedule, with crotamiton cream applied to the whole body from the chin downward, can therefore be recommended as an optimum form of treatment for scabies in infants and young children.
Function:
The mechanism of action of crotamiton is unknown, however it is toxic to the scabies mite.After topical application, crotamiton is absorbed systemically. It has an elimination half-life of 30.9 hours and 4.8-8.8% is excreted in the urine.The most common side effect of crotamiton is skin irritation.