Superiority
Propranolol propionate
Category: Dermatology - Glucocorticoids
Other names: Chloridefloxacin Acetic acid, Chlorpentasone, special skin, anthracene, beclomethasone propionate, clobetasol propionate, clobethasone dipropionate, special skin, propionic acid Clomipramine
(1-oxopropyl) -9-fluoro-21-chloro-pregn-1,4-diene-3,20-dione; 21- Chloro-9-fluoro-11b, 17-dihydroxy-16b-methylpregna-1,4-diene-3,20-d
Ione 17-propionate
(8a, 11beta) -21-chloro-9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate; 14-benzo-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate
Molecular formula: C25H32ClFO5
Molecular weight: 466.97
CAS Number: 25122-46-7
Content: 98.5-102%
Standard level: USP32
Melting point: about 196 ° C
Specific rotation: +98 - + 104 ° C
Appearance: white crystalline powder
Uses: 1, propranolol propionate for the synthesis of high-performance topical glucocorticoid drugs. Has a strong anti-inflammatory, anti-pruritus and capillarity, its anti-inflammatory effect is about hydrocortisone 112.5 times, betamethasone sodium phosphate 2.3 times, fluffy 18.7 times. But also has the role of inhibition of cell mitosis, can effectively penetrate into the skin stratum corneum.
2, topical for chronic eczema, neurodermatitis, psoriasis, palmoplantar pustulosis, lichen planus, discoid lupus erythematosus and other glucocorticoids, topical treatment of pruritus and non-infectious inflammatory skin disease.
3, with anti-inflammatory, anti-allergy, anti-proliferation, immunosuppressive effect.
Can be compound products: ketoconazole. Miconazole nitrate, vitamin A acid to do cream and liniment.
Packing: aluminum foil bag / aluminum listening
Pharmacology and Toxicology: This product is rapid, is the clinical application of high efficiency topical corticosteroids in a strong effect. Has a strong capillarity effect, the anti-inflammatory effect of hydrocortisone 112.5 times, betamethasone sodium phosphate 2.3 times, fluffy 18.7 times. Systemic adverse reactions for the fluffy 3 times, no sodium retention effect, there is a certain role in promoting sodium and potassium excretion.
Pharmacokinetics: This product can be absorbed through the complete skin after external use. After absorption with the system to give corticosteroids in the body of metabolism, mainly in the liver metabolism, the excretion of the kidneys.
Usage and Dosage: topical, thin layer of uniform applied to the affected area, 1 or 2 times a day. In addition to the palm, foot and keratinized hypertrophy of the skin lesions, the general should not be used packet therapy. 1 week can not exceed 50g.
Preparation and specifications: Chlorperethritin propionate ointment: ① 0.05%, 10g: 5mg; ② 0.02%, 10g: 2mg.
Adverse reactions: 1. In the drug site can produce erythema, burning, itching and other stimulating symptoms, even can cause contact dermatitis.
2. Long-term topical local capillaries may be expanded, hirsutism, skin atrophy, wound healing disorders, and make the skin prone to secondary infection, such as folliculitis and fungal infections, packet treatment is more likely to occur.
3. Long-term use in the face can be acne rash, dregs-like dermatitis, facial erythema, oral dermatitis and so on.
4. Long-term use in the skin folds, such as the inside of the stock may appear atrophy, especially in young people prone to.
5. Long-term, large area may be due to the cumulative absorption of drugs, the emergence of glucocorticoid-induced systemic reactions, the emergence of Cushing's syndrome, manifested as hirsutism, acne, full moon face, high blood pressure, osteoporosis, depression , Wound healing and so on. Long-term use of children can inhibit growth and development.
Contraindications: 1. Primary bacterial, fungal and viral and other infectious skin diseases, such as impetigo, tinea corporis, tinea corporis, herpes simplex and other disabled.
2. Allergy to the drug and matrix ingredients or other glucocorticoid allergy disabled.
Pregnant women and lactating women medication: pregnant women and lactating women should weigh the pros and cons after caution. Pregnant women can not be long, large or large.
Child use: baby and children should not be used.
Drug interactions: Not yet clear.
Note: 1. The goods should not be large area or long-term topical. Large area of ??use, can not be more than 2 weeks, so as to avoid systemic absorption caused by reversible hypothalamus - pituitary - adrenal axis inhibition.
2. Can not be applied to the face, armpit, groin and other delicate parts of the skin. Even if the short-term application can also cause skin atrophy and other adverse reactions.
3. pregnant women, breast-feeding women should consider the pros and cons of medication, careful use. Pregnant women can not be long, large or large.
4. baby and children should not be used.
5. The goods can not be used for eyes.
6. If accompanied by skin infections, anti-infective drugs must be used at the same time. Such as the use of the same time, the symptoms of infection did not improve in a timely manner, should be discontinued until the infection control.
KG Pharmaceutical Grade 99% Powder White 1kg / Aluminum Foil Bag
China (Mainland)