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CAS NO.16595-80-5
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Pharmaceutical material Levamisole hcl Levamisole hydrochloride
Synonyms |
Levamisole HCL |
CAS NO |
16595-80-5 |
MF |
C11H13ClN2S |
MW |
240.75 |
Purity |
99% |
Appearance |
White to almost white crystalline powder |
Certification |
ISO 9001, USP, BP |
Standard |
USP |
Usage |
Biological response modifier with anthelmintic activity. |
Packing |
Discreet packing ways as your requirement, 100% go through |
Storage |
Store in cool and dry area and keep away from direct sunlight |
Usage:
Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.
Levamisole is also a good alternative in cases of benzimidazole resistance. Levamisole Hydrochloride
(Levamisole HCl), is an anthelmintic (animals roundworm, hookworm, etc.) agent commonly used in large
livestock such as cattle, pigs and sheep.
It can selectively inhibit succinate dehydrogenase in parasite's muscle so as to stop the reduction of succinic
acid from fumaric acid. Therefore the parasite's muscle metabolism lacks of oxygen and leads to decreasing of
energy.
Description:
Levamisole HCL is absorbed through the gut, can also be absorbed through the skin and is distributed
throughout the body.
Levamisole affects the neurotransmitters and paralyzes the worm (spastic paralysis). The fish then passes the
inactive worms. Good gravel vacuuming is advised after treatment to remove the paralyzed (but still live) worms.
It is not ovicidal, which means it will not affect eggs already present, but it will affect the larval stage of the
worm.To ensure complete eradication of the parasite treat again after remaining eggs have hatched.
Application:
This for the tetramisole sinistral body that can selectively inhibit insect body muscle of succinate
dehydrogenase,fumaric acid cannot revert to succinic acid, which affect anaerobic metabolism of insect body
muscles, reduce energy production.When the insect body contact with neuromuscular depolarization, muscle
sustained contraction occurred paralysis;Quasi choline drug effect of insect body eduction.The active about
tetramisole (racemic form) 1~ 2 times, but a lower side effects.In addition, the drug to the worm microtubule
structure may have inhibitory effect.Levamisole and immune adjustment and immune stimulation.The
roundworm, hookworm, pinworm and dung round nematode disease has good curative effect.Because this
product single dose efficient is higher, so it is suitable for group therapy.The bancroft silk worm, Malay silk worm
and dish tail silk worm worm and activity of microfilariae ethylamine lamictal is high, but the long-term curative
effect is poorer.
Specification:
Product Name |
Levamisole hydrochloride |
CAS No:16595-80-5 |
Items |
Standard |
Results |
Characters |
A white or almost white crystalline powder. |
A white crystalline powder. |
Identification |
Specific optical rotation |
Qualified |
IR |
||
Gives reaction of chlorides |
||
Related substances |
Each of impurities A, B, C, D, E≤0.2% |
A: 0.02%, B: 0.01%, |
Any other impurity≤0.1% |
0.01% |
|
Total impurities≤0.3% |
0.10% |
|
Loss on drying |
≤0.5% |
0.1% |
Sulfated ash |
≤0.1% |
0.03% |
Heavy metals |
≤0.002% |
<0.002% |
Assay |
98.5%~101.0% |
100.1% |
Storage |
Should be protected from light |
protected from light |
CONCLUSION |
The product complies to the standard of BP2011, EP7.0 |