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CAS NO.153439-40-8
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Pharmaceutical material Fexofenadine hydrochloride CAS 153439-40-8
|
Synonyms |
Fexofenadine HCL; Allegra; Benzeneacetic acid |
|
CAS NO |
153439-40-8 |
|
MF |
C32H40ClNO4 |
|
MW |
538.12 |
|
Purity |
99% |
|
Appearance |
Off-White Crystalline Solid |
|
Certification |
GMP, ISO 9001, USP, BP |
|
Standard |
Pharma Grade |
|
Usage |
A metabolite of of terfenadine,a H1-Histamine receptor antagonist |
|
Packing |
Discreet packing ways as your requirement, 100% go through |
|
Storage |
Store in cool and dry area and keep away from direct sunlight. |
Dosage:
Fexofenadine has been demonstrated to be safe and effective for children ages 2-5 years old and 6-11 years old
in treatment of seasonal allergic rhinitis.Recommended doses of fexofenadine in UK labeling referenced below
are:
For adults with seasonal allergic rhinitis (hay fever): 120 mg taken once a day. For children aged 6-12 years with
seasonal allergic rhinitis (hay fever): 30 mg taken twice a day, in the morning and evening. For adults with
chronic urticaria: 180 mg taken once a day.
Use:
Fexofenadine is used for relief from physical symptoms associated with seasonal allergic rhinitis and for
treatment of chronic urticaria.[4] It does not cure but rather prevents the aggravation of allergic rhinitis and chronic
idiopathic urticaria and reduces the severity of the symptoms associated with those conditions, providing relief from
repeated sneezing, runny nose, itchy eyes and general body fatigue.
Description:
Fexofenadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine
can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Fexofenadine is used to treat the symptoms of seasonal allergies (hay fever) in adults and children.
Fexofenadine is also used to treat skin itching and hives caused by a condition called chronic idiopathic urticaria
in adults and children.
Specification:
|
Item |
Specification |
Result |
|
Description |
White to off-white powder or crystalline powder; bitter taste, odorless |
White crystalline powder |
|
chloride |
The solution gives reaction of chloride |
complies |
|
HPLC |
The retention time of the main peak of the test solution corresponds to that of reference peak |
complies |
|
IR |
The infrared spectrum of the testing solution corresponds to that of reference solution |
complies |
|
Residual on ignition |
≤0.1% max |
0.06% |
|
Heavy metals |
Not more than 0.2% |
complies |
|
Impurity B |
Not more than 0.2% |
Not detected |
|
Water |
Not more than 0.5% |
0.34% |
|
Impurity A |
Not more than 0.2% |
0.03% |
|
decarboxylated degradant |
Not more than 0.15% |
0.05% |
|
Single impurity |
Not more than 0.1% |
0.06% |
|
Total impurities |
Not more than 0.5% |
0.2% |
|
Content of chloride |
6.45%~6.75% |
6.52% |
|
Assay |
Not less than98.0% and Not more than102.0% |
99.6% |
|
Conclusion |
meet the USP Standard |
|