Superiority
Pharmacological effects of H1 receptor antagonists, in vivo and in vitro experiments have shown that it can inhibit the release of histamine in mast cells, bitterin have a stronger selectivity. Can significantly reduce the expression of adhesion molecules in epithelial cells, and reduce the release of interleukin-6 in a concentration-dependent manner. It can significantly reduce the release of interleukin-8, granulocyte-macrophage colony stimulating factor and soluble adhesion molecule induced by eosinophils; And can significantly inhibit histamine-induced wind mass and flushing. Because it is not easy through the blood-brain barrier, so no sedative and anticholinergic effect.
Details
Fiscimadine Hydrochloride
Chinese name: fexofenadine hydrochloride
Fenoxidin hydrochloride; alpha, alpha-dimethyl-4- [1-hydroxy-4- [4- (hydroxydiphenylmethyl) -1-piperidine] butyl] Acetate hydrochloride; fisinine hydrochloride; fexofenadine hydrochloride; FEXOFENADINE-D10 旽 CL; fenofenacin hydrochloride;
English name: Fexofenadine hydrochloride
Α-α-dimethyl-4- [1-hydroxy-4- [hydroxypropyliphenylmethyl] -1-piperidinyl] butyl] benzeneacetic acid; Benzeneacetic acid, 4- [1-hydroxy-4 Telfast; Telfast BD; 2- [4- [1-Hydroxy-4- [4- (4- (4-hydroxyphenyl) Diphenyl-methyl) -1-piperidyl] -butyl] phenyl] -2-methyl-propanoic acid hydrochloride; Allegra
CAS Number: 153439-40-8
Molecular formula: C32H40ClNO4
Molecular weight: 538.12
Pharmacological effects of H1 receptor antagonists, in vivo and in vitro experiments have shown that it can inhibit the release of histamine in mast cells, bitterin have a stronger selectivity. Can significantly reduce the expression of adhesion molecules in epithelial cells, and reduce the release of interleukin-6 in a concentration-dependent manner. It can significantly reduce the release of interleukin-8, granulocyte-macrophage colony stimulating factor and soluble adhesion molecule induced by eosinophils; And can significantly inhibit histamine-induced wind mass and flushing. Because it is not easy through the blood-brain barrier, so no sedative and anticholinergic effect.
Application for acute or chronic urticaria, allergic rhinitis, insect biting dermatitis, eczema, skin pruritus and so on.
The outline of the preparation of fexofenadine hydrochloride, preparation methods, pharmacological effects, application, etc. are edited by Chemicalbook Dinghong editor. (2015-12-21)
KG Pharmaceutical grade 99% powdered white 25 kg / plastic drum
China (Mainland)