Trimetazidine hydrochloride
Chinese name: trimetazidine hydrochloride
2 - methyl - 2 - aminopropanol; 1- (2, 2 - methyl - 2 - aminopropanol); 2 - methyl - 2 - aminopropanol; 3,4-trimethoxybenzyl) piperazine dihydrochloride, 97%; 1- (2,3,4-trimethoxybenzyl) piperazine dihydrochloride; 1- (2,3 , 4-trimethoxyphenyl) piperazine dihydrochloride; 1- (2,3,4-trimethoxybenzyl) piperazine dihydrochloride; trimetazidine DIHCL
English name: Trimetazidine dihydrochloride
TRIETAZIDINE HYDROCHLORIDE; TRIMETAZIDINE 2HCL; 1 - (2,3,4-trimethoxyphenyl) methyl) -piperazindihydrochloride; 1- (2,3,4-trimethoxyphenyl) methyl- 2,3,4-trimethoxybenzyl) -piperazindihydrochloride; kyurinett
CAS Number: 13171-25-0
Molecular formula: C14H24Cl2N2O3
Molecular weight: 339.26
EINECS number: 236-117-0
Pharmacological effects of trimetazidine hydrochloride belongs to other types of anti-angina drugs, for the prevention of angina pectoris preventive treatment, dizziness and tinnitus adjuvant symptomatic treatment, with adrenaline, norepinephrine and vasopressin effect, can reduce Vascular resistance, increase coronary and circulatory blood flow, promote myocardial metabolism and cardiac energy production. While reducing myocardial oxygen consumption, thereby improving the balance of supply and demand of myocardial oxygen. Can also increase the tolerance to cardiac glycosides.
Patient trials of angina pectoris showed:
1. Trimetazidine hydrochloride can increase the exercise test tolerance of patients with angina pectoris, from the treatment of dl5 delayed exercise-induced myocardial ischemia, reduce ischemia, but does not cause changes in hemodynamics.
2. Limit rapid fluctuations in blood pressure does not cause significant changes in heart rate, significantly reduce the frequency of angina pectoris.
3. The amount of nitroglycerin was significantly reduced.
Trimetazidine protects the normal functioning of the ion pump and the normal functioning of the membrane-sodium-potassium flow by protecting the energy metabolism of cells in hypoxia or ischemia and preventing the decrease in intracellular ATP levels. Poisoning and prevent myocardial cells in the accumulation of sodium and calcium to protect the cell systolic function and limit the oxygen free radicals caused by cell dissolution and intimal injury, to maintain the stability of the cell environment.
Use of pharmaceutical intermediates
KG Pharmaceutical grade 99.5% powder white 25 kg / plastic drum
China (Mainland)