Keywords

• Losartan potassium salt
• Pharmaceutical material
• Anti hypertensive

Quick Details

• ProName: Pharma grade 99% Pharmaceutical Powder...
• CasNo: 124750-99-8
• Molecular Formula: C22H23ClKN6O
• Appearance: White to Off-White Crystalline Powder
• Application: health & medicine, chemical, pharmaceu...
• DeliveryTime: 24 hours after your payment
• PackAge: Discreet packing ways as your requirem...
• Port: shenzhen
• ProductionCapacity: 1000 Kilogram/Month
• Purity: 99%
• Storage: Store in cool and dry area and keep aw...
• Transportation: As your required
• LimitNum: 10 Gram
• CAS NO: 124750-99-8
• MF: C22H23ClKN6O
• MW: 462.01
• Purity: 99%
• Appearance: White to Off-White Crystalline Powder
• Certification: GMP, ISO 9001, USP
• Standard: Enterprise standard
• Usage: A nonpeptide angiotensin II AT1-recept...

Superiority

1. Quality assurance

With our years of experience, advanced technology and continuous research, our quality is to fully meet the needs of the market to meet the requirements of customers, many customers use our products, we believe that the product is very good. Whether it is a powder, or liquid, yes, we all know, our liquid better.

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4. High quality service 

Our goods packing will not contain any hormone information and can be sent out from different areas of china. At present,the goods customs clearance rate we send to United states and Europe is 99%, As for Canada, Brazil of quite high buckle close rate area, we also have a new way to get through the customs. We also have completely re-send policy to some areas.

Details

Pharmaceutical material Losartan potassium for Antihypertensive 

Description:

1. Losartan potassium,Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5-carboxylic acid metabolite, designated as EXP3174. About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT1 receptors than losartan. Losartan's bioavailability is about 32%.

 
2. Losartan potassium,Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose. Both losartan and EXP3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. The terminal elimination half lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively.

Specification:

Usage:

1.A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

2.antihypertensive, AT1 angiotensin II antagonist

3.Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).