Tacrolimus raw materials CAS NO.104987-11-3

Tacrolimus, also known as FK506, is a fermented product isolated from streptomyces tsukubaensis and its chemical structure is a 23-membered macrolide antibiotic. Is a powerful new immunosuppressive agent, mainly by inhibiting the release of interleukin-2 (L-2), the total inhibition of T lymphocyte effect, than cyclosporine (CsA) 100 times stronger. In recent years, as a liver and kidney transplantation of first-line medication, has been in Japan, the United States and other 14 countries listed. Clinical experiments show that its heart, lung, intestine, bone marrow and other transplantation in the application of a good effect. At the same time FK506 in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune eye disease and other autoimmune diseases also play a positive role.