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Details
Top quality Anti inflamatory Pharmaceutical material Aceclofenac for pian killer
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Product Name |
Aceclofenac
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|
CAS |
89796-99-6
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|
MF |
C16H13Cl2NO4
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|
MW |
354.18
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EINECS |
205-783-4
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Purity |
99%
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Appearance |
White Crystalline Solid
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Certification |
ISO 9001, USP, BP
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|
Grade |
Pharma Grade
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|
Usage |
Aceclofenac is an anti-inflammatory
and analgesic drug
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|
Packing |
Discreet packing ways as your requirement,
100% go through
|
|
Storage |
Store in cool and dry area and keep away from
direct sunlight.
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COA:
|
Item |
Specification |
Result
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Characteristic |
Pure white crystalline powder, slightly hygroscopic
|
Conforms |
|
Solubility |
Sparingly soluble in water, freely soluble in
methanol, ethanol (96%); slightly soluble in acetone;
practically insoluble in ether
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Conforms |
|
Identify |
(A) IR-Spectrum |
(A)conforms
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|
(B) Reaction of sodium salt |
(B)Positive
|
|
PH |
6.5~7.5 |
7.13
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Appearance of solution |
Clear |
Conforms
|
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Absorption of sodium salt≤0.05 |
0.015
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|
Related substances |
Single impurity ≤0.2%
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Conforms |
|
Total impurity ≤0.5%
|
|
Heavy metal |
≤10ppm
|
Conforms |
Description:
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.
It should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children. It should be avoided near term in a pregnant woman because of the risk of having a patent ductus arteriosus in the neonate.
The drug works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandins (PG) which is accountable for pain, swelling, inflammation and fever. The incidence of gastric ulcerogenicity of aceclofenac has been reported to be significantly lower than that of the other frequently prescribed NSAIDs, for instance, 2-folds lesser than naproxen, 4-folds lesser than diclofenac, and 7-folds lesser than indomethacin.
Aceclofenac (C16H13Cl2NO4), chemically [(2-{2, 6-dichlorophenyl) amino} phenylacetooxyacetic acid], is a crystalline powder with a molecular weight of 354.19. It is practically insoluble in water with good permeability. It is metabolized in human hepatocytes and human microsomes to form [2-(2',6'-dichloro-4'-hydroxy- phenylamino) phenyl] acetoxyacetic acid as the major metabolite, which is then further conjugated. According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability. Aceclofenac falls under the BCS Class II, poorly soluble and highly permeable drug.
China (Mainland)