Flumazenil
78755-81-4
Description of Flumazenil
1.Flumazenil (also known as flumazepil, code name Ro 15-1788) is a selective benzodiazepine receptor antagonist primarily available by injection only. It has antagonistic and antidote properties to therapeutically used benzodiazapenes, through competitive inhibition.
2.It was first introduced in 1987 by Hoffmann-La Roche under the trade name Anexate, but only approved by the FDA on December 20, 1991. Flumazenil went off patent in 2008 so at present generic formulations of this drug are available. Intravenous flumazenil is primarily used to treat benzodiazepine overdoses and to help reverse anesthesia. Administration of flumazenil by sublingual lozenge and topical cream has also been tested.
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Usage of Flumazenil
1. central nervous system stimulant.
2. pharmaceutical raw materials
3. As an antagonist benzodiazepine class of drugs, used against Gram benzodiazepine drugs overdose after sedation and disorientation, and having anticonvulsant activity and antiepileptic effects, can also be used halothane anesthesia recovery due to alcoholism and cirrhosis of the liver caused by encephalopathy, diagnostic medicine as unexplained loss of consciousness, and for identifying the benzodiazepine class and other poisoning or brain damage.
China (Mainland)