Superiority
Mibolerone
Product Name Mibolerones Powder
CAS Registry Number 3704-09-4
EINECS 223-046-5
Molecular formula C20H30O2
Molecular weight 302.45
Purity 99%
Grade Pharmaceutical Grade
Appearance white crystalline powder
Details
Mibolerone
Product Name Mibolerones Powder
CAS Registry Number 3704-09-4
EINECS 223-046-5
Molecular formula C20H30O2
Molecular weight 302.45
Purity 99%
Grade Pharmaceutical Grade
Appearance white crystalline powder
Mibolerones is a potent anabolic steroid which is both higher affinity and more selective for the androgen receptor than metribolone.
The first step involves extending the conjugation of the enone function by an additional double bond. Chloranil (tetrachloroquinone) is the forerunner of dichlorodicyanoquinone (DDQ), a reagent used extensively for introducing additional unsaturation in the progestin and corticoid series. In the case at hand, heating acetate with chloranil gives the diene, and reaction of that compound with methylmagnesium bromide in the presence of cuprous chloride leads to addition of the methyl group to position 7 at the end of the conjugated system. The stereochemistry of the product again illustrates the preference for additions from the backside. The alcohol at C17 is then oxidized to a ketone. Enamines are commonly used to activate adjacent functions; they are also not infrequently used, as in this case, as protecting groups.
Thus, reaction of the intermediatewith pyrrolidine gives enamine. This transformation emphasizes the clear difference in reactivity between ketones at C7 and C17. A second methyl Grignard addition gives the corresponding 17a-methyl derivative. Hydrolysis of the enamine function then affords mibolerone.
Mibolerone is an oral anabolic steroid, structurally derived dimethylated nandrolone. This agent is specifically 7,17- dimethylated nandrolone, significantly more potent as an anabolic and androgenic agent than its non-methylated parent. Over the years, mibolerone has earned a reputation among bodybuilders as being one of the strongest steroids ever made. This is correct in a technical sense, as it is one of only a select few commercial steroid products effective in microgram, not milligram, amounts. During standard animal assays, mibolerone was determined to have 41 times the anabolic activity of methyltestosterone when given orally. In contrast, it had only 18 times the androgenic activity.
Although both properties are strongly pronounced with this agent, it retains a primarily anabolic character (in a relative sense). Estrogenic and progestational properties are also very pronounced with this drug, however. Among athletes it is most commonly applied during bulking phases of training, or to stimulate aggression before a workout or competition.
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