Pregabalin(Lyrica)
CAS:148553-50-8
Pregabalin, is a medication used to treat epilepsy, neuropathic pain, fibromyalgia
Gabapentinoid
target of the drugs gabapentin and pregabalin. Clinically-used gabapentinoids include gabapentin (Neurontin) and pregabalin (Lyrica) as well as a gabapentin
Mirogabalin
pregabalin. Similarly to these drugs, mirogabalin binds to the α2δ calcium channels (1 and 2), but with significantly higher potency than pregabalin.
Orexigenic
valproate, carbamazepine and gabapentin α2δ VDCC ligands - gabapentin, pregabalin Ghrelin receptor agonists such as anamorelin, GHRP-6, ibutamoren, ipamorelin
Description
regabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23.
Pregabalin is a white to off-white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is 1.35.
LYRICA (pregabalin) Capsules are administered orally and are supplied as imprinted hard-shell capsules containing 25, 50, 75, 100, 150, 200, 225, and 300 mg of pregabalin, along with lactose monohydrate, cornstarch, and talc as inactive ingredients. The capsule shells contain gelatin and titanium dioxide. In addition, the orange capsule shells contain red iron oxide and the white capsule shells contain sodium lauryl sulfate and colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells. The imprinting ink contains shellac, black iron oxide, propylene glycol, and potassium hydroxide.
China (Mainland)