Jinan Jiage biological technology co., LTD(expird)
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CAS NO.137-58-6
Enterprise Standard(10-100)Metric TonEnterprise Standard(101-1000)Metric Ton
99% Purity Pharmaceutical Anesthetic Powder Lidocaine For Pain Killer
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CAS NO |
137-58-6 |
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Synonyms |
xylocaine |
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MF |
C14H22N2O |
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MW |
234.34 |
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EINECS |
205-302-8 |
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Purity |
99% |
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Melting point |
66-69°C |
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Storage temp |
Store at RT |
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Solubility ethanol |
4 mg/mL |
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Certification |
GMP, ISO 9001, USP, BP |
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Standard |
pharma grade |
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Usage |
Topically used to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery. |
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Packing |
Discreet packing ways as your requirement, 100% go through |
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Storage |
Store in cool and dry area and keep away from direct sunlight |
Uses:
This product is a local anesthetics of amide derivatives，and widely used in surface anesthesia, anesthesia, conduction anesthesia and epidural anesthesia. The LD50 of oral lidocaine hydrochloride to mice was 290 mg/kg.
Used as a local anesthetic
Usage Lidocaine (Alphacaine)is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Histamine is responsible for many features of allergic reactions. Lidocaine (Alphacaine)is a second-generation antihistamine agent closelyst
Usage antihypertensive
Usage Anticonvulsant
Usage Antiarrhythmic Agents, Anesthetics
Chemical property:
Lidocaine is white needle like crystals, and its melting point is 68-69℃; boiling point is 180-182℃ (0.53kPa), soluble in ethanol in 159-160℃ (0.267kPa), ether, benzene, chloroform and oil, do not dissolve in water. In common use radical hydrochloride, lidocaine hydrochloride (C14H22N2O • HCL, [73-78-9]) is a white crystalline powder. Melting point 127-129℃, and the monohydrate melting point is 77-78℃. Easily soluble in water, 0.5% aqueous solution pHO 4.0-5.5. Odorless, bitter taste.
Description:
Lidocaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidocaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidocaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the poisoning of lidocaine and other side effects, can be added in the anesthetic epinephrine.
Lidocaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidocaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.
Application:
Topical lidocaine has been shown in some patients to relieve the pain of postherpetic neuralgia (a complication of shingles), though there is not enough study evidence to recommend it as a first-line treatment. IV lidocaine also has uses as a temporary fix for tinnitus. Although not completely curing the disorder, it has been shown to reduce the effects by around two thirds. Lidocaine hydrochloride injection administered intravenously or intramuscularly, is specifically indicated in the acute management of ventricular arrhythmias such as those occurring in relation to acute myocardial infarction, or during cardiac manipulation, such as cardiac surgery.