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Details
99% Purity Antifungal Pharmaceutical powder Griseofulvin with BP Standard
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Product Name |
Griseofulvin
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CAS |
126-07-8
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MF |
C17H17ClO6
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MW |
352.77
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EINECS |
204-767-4
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Purity |
99%
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Appearance |
White powder
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Certification |
ISO 9001, USP, BP
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Standard |
BP Standard
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Grade |
Pharma Grade
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Usage |
It is an antifungal drug. It is used both in animaland
in humans, to treat rigworm infections of the skin and
nails. It is derived from the mold Penicillium griseofulvum.
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Packing |
Discreet packing ways as your requirement, 100% go through
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Storage |
Store in cool and dry area and keep away from direct sunlight
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Payment |
Bank Transfer, Moneygram, , Bitcoin
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Function:
In medicine, this product mainly has good antibacterial effect against Trichophyton, Microspores, and Epidermophyton fungi. However, it has no anti-bacterial effect on Candida, Cryptococcus, Histoplasma, Sporothrix, Blastomyces, and Coccidioides and so on. Mechanism of action of is drug is through interfering with the biosynthesis of nucleic acids of fungal and further inhibiting of its growth.
In agriculture, this product has good inhibitory effect on the Ascomycetes, Basidiomycetes, Deuteromycetes and some kinds of algae. However, it is not effective in treating oomycetes whose cell wall containing no chitin content. After spraying melons and other crops, it can be transferred into the branch, leaves and fruits through inner absorption, the absorption of water via rrot, as well as transpiration effect, and further preventing the fungal diseases; according to the study of Brandeis et al. (1946), at a concentration as low as even 10 mg/L or 1 mg/L, griseofulvin can already can make the mycelium of Bctrytis allill be stout, deformed and exhibit spiral bending, also cause: large number of abnormal branching; the development retardation of germinated spores, and loss of apical dominance; thus it has uptake therapeutic effects on a variety of plant diseases, especially powdery mildew, gray mold diseases; Griseofulvin has a more prominent antibacterial activity than the bactericidal activity.
Description:
Griseofulvin is a non-polyene class antifungal antibiotics; it can strongly inhibit the mitosis of fungal cell and interfere with the fungal DNA synthesis; it can also bind to tubulin to prevent fungal cell division. It has been applied to clinical medicine since 1958 and has currently been widely used for treating the fungal infections of the skin and the stratum corneum with strong inhibitory effects on Trichophyton rubrum and Trichophyton tonsorans, etc. Griseofulvin is not only a widely used antibiotic for clinical treatment of fungal infections of the skin and cuticle, but also applied in agriculture for prevention and treatment of fungal diseases; for example, it has a special efficacy on treating a kind of candidiasis in apple which can cause infection during pollination.
Specification:
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Item |
Specification |
Result
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Characteristics |
A yellowish-white,
microfine powder
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A yellowish-white,
microfine powder
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Melting point |
220ºC About 220ºC |
218.4ºC-219.4ºC
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Specific optical rotation |
+354o~+364o |
+356o
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Identification |
Meets the requirements |
Meets the requirements
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Check-up Particles size |
Meets the requirements |
Meets the requirements
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Acidity |
0.25g consumed 0.02mol/l NaOH
not more intensely coloured than
reference solution Y4
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0.6ml |
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Clarity and colour of solution |
The solution is clear and not more
intensely coloured than reference solution Y4
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Y5~Y6
Clear Y5~Y6 |
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Matter soluble in petroleum spirit |
≤0.2% |
0.1%
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Sulphated ash |
≤0.2% |
0.1%
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Related substances |
-Cl:<0.60 -H<0.15 |
-Cl:0.48-H:0.04
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Loss on drying |
≤1.0% |
0.1%
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Abnormal toxicity |
Meets the requirements |
Meets the requirements
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assay(on the anhydrous substance) |
97.0%~102.0% |
98.3% |
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Conclusion |
The above certificate of analysis is in compliance with BP/EP,meets the standard requirements.
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China (Mainland)