Jinan Jiage biological technology co., LTD(expird)
Free supplier
- Free
supplier - 8th
years
Free supplier
Business Type:Trading Company
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
CAS NO.125-84-8
Enterprise Standard(10-100)GramEnterprise Standard(101-1000)Gram
High Purity Pharmaceutical Material Cytadren Aminoglutethimide
|
Synonym |
Aminoblastin; Cytadren; Elipten; Orimenten |
|
CAS No |
125-84-8 |
|
EINECS No |
204-756-4 |
|
Molecular formula |
C13H16N2O2 |
|
Molecular weight |
232.28 |
|
Content |
98%min |
|
Appearance |
White powder |
|
Certification |
GMP, USP, BP |
|
Standard |
Enterprise standard |
|
Usage |
Inhibit Aromatase and Desmolase |
|
Packing |
Discreet packing ways as your requirement, 100% go through |
|
Storage |
Store in cool and dry area and keep away from direct sunlight |
Usages:
It is an inhibitor of adrenocortical steroid synthesis and also adrenal estrogen synthesis by inhititing aromatization enzyme. It is indicated in the treatment of advanced breast cancer and breast cancer after surgery. It is also used to decrease the adrenal secretion of cortisol.
How this drug works:
Aminoglutethimide is a type of hormone therapy. Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. (For example, the hormone testosterone made in the testicles is responsible for male characteristics such as deepening voice and increased body hair.) The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells. Hormone therapies work by stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell.The different types of hormone therapies are categorized by their function and/or the type of hormone that is effected.
Aminoglutethimide is an adrenal steroid inhibitor, which means it interferes with the hormones produced by the adrenal gland. The adrenal glands are located on top of the kidneys. The outer portion of the adrenal gland (the adrenal cortex) produces hormones called corticosteroids. When these corticosteroids are blocked from being made, they are not able to signal the body to produce other hormones such as estrogen, androgens, glucocorticoids, and mineralocorticoids. The resulting decrease of estrogens and androgens interferes with the stimulation of cancer growth in tumors that are influenced by these hormones.
Function:
Aminoglutethimide is classified as an adrenal steroid inhibitor. Aminoglutethimide produces its effects by suppressing hormones that are produced by the adrenal glands. Normally, the hormones produced by adrenal glands stimulate the production of other hormones in the body, including estrogen, androgens, and corticosteroids. Cancer of the adrenal glands may be associated with excess steroid production in the body, which may ultimately cause Cushing's syndrome. Aminoglutethimide suppresses the production of the steroids, resulting in a decrease in symptoms. Furthermore, estrogens and androgens may play a role in the growth of some types of cancer cells. Inhibiting their production may reduce the growth of cancers such as hormone responsive advanced breast and prostate cancers.